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KMID : 0359020070340060339
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Korean Journal of Gastrointestinal Endoscopy
2007 Volume.34 No. 6 p.339 ~ p.342
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Tuberculous Meningitis in a Patient with Crohn’s Disease, Which was Treated with Infliximab
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Kim Youn Ho
Lee Beom-Jae
Cheong Hee-Jin
Park Jong-Jae
Kim Jae-Seon
Han Woo-Sik
Lee Won-Woo
Oh Sung-Nam
Choi Do-Won
Park Young-Tae
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Abstract
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Clinical trials of tumor necrosis factor (TNF) inhibitor have demonstrated significant efficacy in those patients with Crohn’s disease that is not responsive to other anti- inflammatory drug. Infliximab is a human-murine chimeric monoclonal antibody with a high binding affinity and specificity for TNF-α. Yet therapy with infliximab is associated with an increased risk of opportunistic infection, and especially tuberculosis. Here we reported on a case of tuberculous meningitis in 26-year-old man, and he was treated with infliximab for uncontrolled and fistulous Crohn’s disease. We also include a review of the literature.
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KEYWORD
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Crohn’s disease, Tuberculous meningitis, Infliximab
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